Reference of 116986-09-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116986-09-5, name is Methyl 3-(bromomethyl)picolinate. A new synthetic method of this compound is introduced below.
Step 1 : Preparation of methyl 3-[(2,3,5-trichloro-4-pyridyl)methylsulfanylmethyl]pyridine-2- carboxylate To a solution of S-[(2,3,5-trichloro-4-pyridyl)methyl] ethanethioate (17.7 g, 65.4 mmol) in methanol (200 ml) was added potassium carbonate (10.9 g, 78.9 mmol) and the mixture stirred for 5 min at room temperature. Methyl-3-(bromomethyl)pyridine-2-carboxylate (16.6 g, 72.2 mmol) was then added and the reaction mixture was stirred at room temperature for 1 h. Water was added and the organic phase separated. The aqueous phase was extracted with ethyl acetate and the combined organic phases were washed with brine and dried over sodium sulfate. The residue after filtration and evaporation of the solvent was chromatographed on silica gel eluted with hexane:ethyl acetate (1 :1 ) to give 21.7 g (88%) of the desired product. 1H NMR (CDCIs): 8.62 (d, 1 H); 8.25 (s, 1 H); 7.87 (d, 1 H); 7.41 (dd, 1 H); 4.27 (s, 2H), 3.98 (s, 5H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116986-09-5, its application will become more common.
Reference:
Patent; BASF SE; BESONG, Gilbert; WITSCHEL, Matthias; REINGRUBER, Ruediger; KRAUS, Helmut; SEITZ, Thomas; PARRA RAPADO, Liliana; NEWTON, Trevor William; KRAeMER, Gerd; EVANS, Richard Roger; RACK, Michael; WO2014/187705; (2014); A1;,
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