Reference of 1195-59-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1195-59-1 as follows.
Example 15 2,6-Bis(bromomethyl)pyridine. To pyridine-2,6-diyldimethanol (2 g, 14 mmol) was added 60% HBr (15 mL) slowly. The reaction was heated at 125 C. for 6 h then cooled to room temperature. The resulting residue was dissolved in H2O (50 mL) to give a yellow solution. To this solution was added saturated NaHCO3 to pH 8. The resulting aqueous solution was extracted with CH2Cl2 (4×50 mL), and the combined organic layers were dried over Na2SO4. The solvent was removed by rotary evaporation, and the resulting material was purified by flash column chromatography (EtOAc/hexanes, 1:9-1:4) to yield 2,6-bis(bromomethyl)pyridine (3.5 g, 96%) as a white solid: 1H NMR (500 MHz, CDCl3) delta 4.53 (s, 4H), 7.36-7.38 (d, J=8.0 Hz, 2H), 7.68-7.71 (dd, J=7.5, 8.0 Hz, 1H); 13C NMR (125 MHz, CDCl3) delta 33.8, 123.1, 138.4, 157.0; LC-TOF (M+H+) calcd for C7H8Br2N 263.90235, found 263.90193.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1195-59-1, its application will become more common.
Reference:
Patent; Silverman, Richard B.; Xue, Fengtian; US2010/203613; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem