The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1256808-59-9, name is 5-Fluoro-3-methylpicolinic acid. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H6FNO2
Example 49 N-(3-((2R,5S)-6-amino-3,3,5-trifluoro-2,5-dimethyl-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-5-fluoro-3-methylpicolinamide Prepared from (3S,6R)-6-(5-amino-2-fluorophenyl)-3,5,5-trifluoro-3,6-dimethylpiperidine-2-thione and 5-fluoro-3-methylpicolinic acid LC-MS (m/z) 427.1 (MH+) tR=0.54 minutes (Method A) 1H NMR (600 MHz, DMSO-d6) delta 10.51 (s, 1H), 8.53 (dd, J=2.7, 0.4 Hz, 1H), 7.89-7.84 (m, 1H), 7.81 (ddd, J=9.8, 2.7, 0.6 Hz, 1H), 7.75 (dd, J=7.2, 2.7 Hz, 1H), 7.12 (dd, J=12.0, 8.8 Hz, 1H), 6.22 (s, 2H), 2.75-2.61 (m, 1H), 2.58 (s, 3H), 2.49-2.37 (m, 1H), 1.67 (d, J=22.7 Hz, 3H), 1.62 (s, 3H)
With the rapid development of chemical substances, we look forward to future research findings about 1256808-59-9.
Reference:
Patent; H. LUNDBECK A/S; Juhl, Karsten; Marigo, Mauro; Tagmose, Lena; Jensen, Thomas; US2015/232449; (2015); A1;,
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