Adding a certain compound to certain chemical reactions, such as: 131747-53-0, (6-(Trifluoromethyl)pyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 131747-53-0, blongs to pyridine-derivatives compound. Recommanded Product: 131747-53-0
TEA (1.4 g, 1.9 mL, 14 mmol) was added dropwise to 0 C(6-trifluoromethyl-pyridin-2-yl) -methanol(1.61 g,9.09 mmol) in DCM (20 mL) was added MsCl (1.2 g, 11 mmol) under nitrogen,The reaction was then continued at 0 C. The reaction mixture was concentrated under reduced pressure, then saturated aqueous sodium bicarbonate (40 mL)Dichloromethane (50 mL x 3)The organic phase was dried over anhydrous Na2SO4 and the concentrated crude product was isolated by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 7 /3) to give 2.2 g of a yellow solid, yield: 95%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,131747-53-0, (6-(Trifluoromethyl)pyridin-2-yl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Zhou Youbo; Yang Tiping; He Wei; Zhang Yingjun; Zheng Changchun; (103 pag.)CN106749268; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem