13534-99-1, Adding a certain compound to certain chemical reactions, such as: 13534-99-1, 2-Amino-3-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13534-99-1, blongs to pyridine-derivatives compound.
Example 28: 8,9-Dimethoxy-5H-benzo[cU1 ,81naphthyridin-6-one (28); 2-Amino-3-bromopyridine (500 mg, 2.89 mmol), 4,5-dimethoxy-2- methoxycarbonylphenylboronic acid (1.04 g, 4.33 mmol), palladium(ll) acetate (30 mg, 0.12 mmol), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (90 mg, 0.23 mmol), and potassium carbonate (1.2 g, 8.67 mmol) were dissolved in dioxane / H2O (1 1 ml_, 10 / 1 , v / v), and stirred overnight at 100 0C. The reaction mixture was concentrated, suspended in EtOAc / H2O, and filtered. The precipitate was washed with EtOAc / H2O, and dried under vacuum to provide 27 (600 mg, 81 % yield) as a white solid. LC-MS (M+H = 257, obsd. = 257). 1H NMR (400 MHz, d6- DMSO) : delta 8.83 (dd, 1 H), 8.42 (dd, 1 H), 7.92 (s, 1 H), 7.71 (s, 1 H), 7.29 (m, 1 H), 4.04 (s, 3H), 3.91 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13534-99-1, its application will become more common.
Reference:
Patent; MERCK SERONO S.A.; WO2009/108670; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem