Adding a certain compound to certain chemical reactions, such as: 13575-41-2, Thiazolo[4,5-b]pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13575-41-2, blongs to pyridine-derivatives compound. Quality Control of Thiazolo[4,5-b]pyridin-2-amine
(4) 15.7 g of isoamyl nitrite was added dropwise to a solution of 8.1 g of compound 4 in 160 ml of dry tetrahydrofuran(20min), and then heated to 65 degrees reflux 4h; TLC detection reaction should be terminated, down to room temperature, filter out nothing,Filter cake ethyl acetate (50 mL * 3), spin dry system, purified by column (200-300 mesh silica gel column) petroleum ether:Ethyl acetate = 1: 1),(Product 5) was obtained in a yield of 46.6%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13575-41-2, its application will become more common.
Reference:
Patent; Sphinx Scientific Laboratory (Tianjin) Co., Ltd.; Yao, Qingjia; Xu, Yangjun; Wu, Simin; (6 pag.)CN104402910; (2017); B;,
Pyridine – Wikipedia,
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