Reference of 1370347-50-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1370347-50-4 as follows.
Methanesulfonyl chloride (32.21g, 281.2 mmol) was slowly added to a mixed solution of Example 25F (18g,94mmol) and triethylamine (28.45g, 281mmol) in dichloromethane (400mL) at 0C under an ice bath. The reactionsolution was stirred at room temperature for 4 hours. Upon the completion of the reaction, the reaction was quenchedwith water and extracted with dichloromethane (500mL 3 3). The combined organic phase was dried over anhydroussodium sulfate and evaporated to dryness. The residue was purified by column chromatography to give Example 24G(24g, 88.9mmol, yield 94.8%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1370347-50-4, its application will become more common.
Reference:
Patent; Harbin Zhenbao Pharmaceutical Co., Ltd.; Medshine Discovery Inc.; CHEN, Shuhui; CHEN, Zhengxia; DAI, Meibi; XIE, Cheng; LI, Peng; ZHANG, Yang; LIANG, Guibai; WANG, Qiang; LIAO, Jiangpeng; SUN, Fei; HU, Guoping; LI, Jian; (166 pag.)EP3333157; (2018); A1;,
Pyridine – Wikipedia,
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