Application of 1462-86-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1462-86-8, name is 3-Aminopicolinic acid, molecular formula is C6H6N2O2, molecular weight is 138.12, as common compound, the synthetic route is as follows.
Step B. 3-Amino N (cyclohexyloxy)pyridine-2-carboxamide; HATU (2.32 g, 6.10 mmol) was added to a solution of O-cyc1ohexylhydroxylamine (prepared as ref. A. Miyake et al J. Antibiot. 53 (10), 1071-1085, 2000) (0.86 g, 7.50 mmol), DIPEA (1.29 g, 10.0 mmol) and 3-aminopyridine-2-carboxylic acid (0.69 g, 5.00 mmol) in DMF (20 mL) at 0 C. The mixture was stirred overnight at room temperature, diluted with EtOAc (200 mL), washed with H20 (2×10 mL), brine (10 mL) and dried over Na2S04. After evaporation of the solvent, the title compound was purified by MPLC on silica gel using hexane/EtOAc (1: 1) (1.35 g, 100 %) as a white solid. 1H NMR (400 MHz, CDC13) 8 1.30 (m, 2 H), 1.52 (m, 4 H), 1.80 (m, 2 H), 2.06 (m, 2 H), 3.96 (m, 1 H), 5.93 (s, 2 H), 7.00 (dd, J=8.40, 1.37 Hz, 1 H), 7.17 (dd, J=8.40, 4.30 Hz, 1 H), 7.82 (dd, J=4.30, 1.37 Hz, 1 H), 10.12 (s, 1 H).
The chemical industry reduces the impact on the environment during synthesis 1462-86-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; AstraZeneca AB; WO2005/115986; (2005); A1;,
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