Related Products of 1597-32-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1597-32-6, name is 2-Amino-6-fluoropyridine, molecular formula is C5H5FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred and ice-cooled solution of commercial 2-(4-chloro-phenyl)- quinoline-4-carboxylic acid (1.400 g, 4.9346 mmol) and 2-amino-6-fluoropyhdine (0.664 g, 5.9215 mmol) in dichloromethane (20 ml), triethylamine (3.495 g, -4.8 ml, 34.5422 mmol) is added, followed by portion-wise addition of 1 – propanephosphonic acid cyclic anhydride (12.561 g, 19.7384 mmol) and the mixture is allowed to attain room temperature spontaneously overnight. The resulting mixture is diluted with dichloromethane (-30 ml), washed with water and brine, dried (MgSO4), and evaporated to afford a brown gummy residue (1.860 g, 100% mass balance). This is purified by column chromatography eluting with 8% ethyl acetate in hexane, to obtain the title compound as a pale yellow solid (0.474 g, -18% yield). M.p. 200-2010C.
According to the analysis of related databases, 1597-32-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NEUROSEARCH A/S; NARDI, Antonio; CHRISTENSEN, Jeppe, Kejser; PETERS, Dan; DYHRING, Tino; WO2010/20672; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem