Synthetic Route of 169205-95-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.169205-95-2, name is 2-(Methylthio)oxazolo[4,5-b]pyridine, molecular formula is C7H6N2OS, molecular weight is 166.2, as common compound, the synthetic route is as follows.
Preparation of fert-Butyl [2-([l ,3]oxazolo[4,5-]pyridin-2-ylamino)ethyl]carbamate(P^ />-NH(CH2)2NHBOCA mixture of 2-(methylthio)-[l,3]-thiazolo[4,5-&]pyridine (100 mg, 0.602 mmol) and /erf-butyl (2-aminoethyl)carbamate (193 mg, 1.204 mmol) was heated neat at 85C for 1 h. The reaction mixture was cooled to room temperature, the residue obtained was purified by silica gel column chromatography using 2% methanol in chloroform as eluent to give the title compound as an off-white solid; 1.40 (s, 9H), 3.45-3.52 (m, 2H), 3.65- 3.70 (m, 2H), 6.90-6.96 (m, IH), 7.45 (d, J = 7.2 Hz, IH), 8.17-8.23 (m, IH); ESI- MS (m/z) 279.11 (MH)+.
Statistics shows that 169205-95-2 is playing an increasingly important role. we look forward to future research findings about 2-(Methylthio)oxazolo[4,5-b]pyridine.
Reference:
Patent; GLENMARK PHARMACEUTICAL S.A.; IRLAPATI, Nagoswara, Rao; THOMAS, Abraham; KURHE, Deepak, Kantilal; SHELKE, Sandeep, Yadunath; KHAIRATKAR, JOSHI, Neelima; VISWANADHA, Srikant; MUKHOPADHYAY, Indranil; WO2010/10435; (2010); A2;,
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