The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17570-98-8, name is 2-(Bromoacetyl)pyridine hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 17570-98-8
NaH (60%) (120 mg, 3 mmol) was added into a solution of dichloro-2- (2,2,2-trifluoro-ethyl)-1 H-benzoimidazole (269 mg, 1 mmol) in DMF (5 ml) at O0C. The resulting mixture was stirred at 0C for half hour. 2-bromo-1 -(2- pyridiny)-l-ethanone hydrobromide (421.4 mg, 1.5 mmol) was then added to the reaction mixture at 0C. The reaction temperature was raised to 25C and then the reaction mixture was stirred for 18 hours. NH4CI (aq.) was added and extracted with EtOAc. The organic layer was washed with brine, then dried over anhydrous MgSO^ The solvent was distilled out under reduced pressure. Column chromatography (silica gel, EtOAc / hexanes 0% to 70%) yielded the title compound as a yellow solid.MS m/z (M+H) 388, (M-H) 386.
With the rapid development of chemical substances, we look forward to future research findings about 17570-98-8.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/39215; (2006); A2;,
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