Reference of 178876-82-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 178876-82-9, name is Methyl 6-amino-5-bromopicolinate. A new synthetic method of this compound is introduced below.
c. 6-Amino-5-bromopyridine-2-carboxylic acid methyl ester (2 g) and a 50% aqueous solution of chloroacetaldehyde (2.8 mL) in isopropanol (100 mL) were stirred heated to 70C overnight. More of the 50%> aqueous solution of chloroacetaldehyde (0.35 mL) was added at room temperature and the mixture was stirred heated to 80C for an additional 3 hours. The mixture was cooled to room temperature, loaded on silica and purified by chromatography (Si02, Heptane/EA) to afford afford 8-bromo-imidazo[l,2-a]pyridine-5-carboxylic acid methyl ester as a solid (2.3 g). MS (ES): M/Z [M+H]=255. IH NMR (400 MHz, CHLOROFORM-d): 4.00 (s, 3H), 7.51 (d, J=7.6 Hz, IH), 7.63 (d, J=7.8 Hz, IH), 7.82 (s, IH) and 8.90 (s, IH)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,178876-82-9, Methyl 6-amino-5-bromopicolinate, and friends who are interested can also refer to it.
Reference:
Patent; MERIAL LIMITED; LE HIR DE FALOIS, Loic, Patrick; LEE, Hyoung, Lk; WILKINSON, Douglas, Edward; BECK, Brent, Christopher; WO2011/75591; (2011); A1;,
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