Adding a certain compound to certain chemical reactions, such as: 100202-78-6, 2-(Bromomethyl)-6-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(Bromomethyl)-6-fluoropyridine, blongs to pyridine-derivatives compound. Quality Control of 2-(Bromomethyl)-6-fluoropyridine
Preparation 45; ; [9-(6-Fluoro-pyridin-2-ylmethyl)-6-trifluoromethoxy-2,3,4,9-tetrahydro-lH- carbazol-3-yl]-carbamic acid benzyl esterAdd Cs2CO3 (6.44 g, 19.8 mmol) to a solution of (6-trifluoromethoxy-2,3,4,9-tetrahydro-lEta-carbazol-3-yl)-carbamic acid benzyl ester (Preparation 43) (4.00 g, 9.88 mmol) and 2-bromomethyl-6-fluoropyridine (Preparation 44) (3.11 g, 13.8 mmol) in DMF (40 mL). Heat the resulting mixture to 50 0C for 18 h and then dilute with EtOAc (120 mL). Wash the organics with water (3 x 40 mL), dry (MgSO4), filter, and concentrate to give the crude product (5.40 g) as a brown oil. Purify the crude product on silica gel (120 g) eluting with 25-45% EtOAc/hexanes to afford 2.85 g (56%) of the title compound as a tan oil. MS (ES): m/z 514 (M+l); HPLC (Method A): Rt = 4.54 min (95%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,100202-78-6, 2-(Bromomethyl)-6-fluoropyridine, and friends who are interested can also refer to it.
Reference:
Patent; ELI LILLY AND COMPANY; WO2007/2181; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem