Synthetic Route of 100202-78-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100202-78-6, name is 2-(Bromomethyl)-6-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: The commercially available starting material 1 (1.0mmol) was suspended in acetonitrile (10mL) containing K2CO3 (2.0mmol). The reaction was treated with an appropriately substituted arylalkyl derivatives 2a-o and 4a-4h (1.2mmol) and heated under reflux for 8h. The reaction progress was monitored using silica gel TLC with DCM/MeOH as mobile phase. Upon completion, the acetonitrile was evaporated in vacuo and the mixture was then poured into water, which was extracted with DCM, washed with brine, dried over anhydrous Na2SO4 and purified by chromatography (DCM/MeOH) on silica gel to afford the target compounds.
According to the analysis of related databases, 100202-78-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wang, Zhi-Min; Cai, Pei; Liu, Qiao-Hong; Xu, Ding-Qiao; Yang, Xue-Lian; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 282 – 297;,
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