Adding a certain compound to certain chemical reactions, such as: 628691-93-0, 2-Chloro-3-fluoroisonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Chloro-3-fluoroisonicotinic acid, blongs to pyridine-derivatives compound. Safety of 2-Chloro-3-fluoroisonicotinic acid
To a mixture of 2- chloro-3-fluoro/5onicotinic acid (3.55 g, 20.2 mmol) and triethylamine (8.4 mL, 6.13 g, 60.6 mmol) in dry toluene (40 mL) and dry 7-BuOH (40 mL) under nitrogen, was added diphenylphosphoryl azide (6.51 mL, 8.27 g, 30.1 mmol). The reaction was heated at 110 C for 3 hours then cooled to ambient temperature. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in DCM (50 mL) and washed with water (40 mL). The aqueous phase was extracted with DCM (2 x 40 mL) and the combined organic extract was dried over MgS04, and concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (0-20 % EtOAc in DCM) to give the title compound as a yellow oil (3.8 g, 71 % yield). NMR (400 MHz, CDC13): delta 8.09-8.07 (m, 2H), 6.98 (br s, 1H), 1.54 (s, 9H).
The synthetic route of 628691-93-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/35039; (2012); A1;,
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