Reference of 503000-87-1 ,Some common heterocyclic compound, 503000-87-1, molecular formula is C7H6ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The intermediate 2-chloro-6-methoxynicotinic acid (3.0 g, 16.00 mmol, 1.0 eq),Potassium carbonate (2.48g,17.94 mmol, 1.1 eq) and methyl iodide (3.07 g, 21.6 mmol, 1.4 eq)Add to DMF solution (35mL), heat to 50 CReaction for 12 hours. The reaction was completely detected by LC-MS and was cooled to room temperature.The reaction solution was directly concentrated under reduced pressure.The crude product was purified by silica gel column chromatography (100-200 mesh silica gel)The product was obtained as a white solid (1.5 g, yield: 47%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,503000-87-1, its application will become more common.
Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; (67 pag.)CN109810041; (2019); A;,
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