Adding a certain compound to certain chemical reactions, such as: 393-55-5, 2-Fluoronicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
Weigh 10 g (70.87 mmol) of 2-fluoronicotinic acid in 330 mL of anhydrous tetrahydrofuran and stir overnight in an ice bath. A small portion is slowly added with 4.3 g (113.07 mmol) of LiA1H4 to generate a large amount of bubbles. As the amount of LiAlH4 added increases, The reaction solution was yellow and turbid with white turbidity. After the addition, the reaction was continued for 2omin. TLC monitored the reaction. The reaction was completely quenched by slowly adding 10.6 mL of water to generate a large amount of bubbles and solids. The filtrate was filtered off and the solvent was evaporated under reduced pressure to give a yellow liquid. 7.78g, ready for use.
The synthetic route of 393-55-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Chinese People’s Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute; Li Song; Zheng Zhibing; Lin Feng; Gong Zehui; Lu Xinqiang; Zhou Xinbo; Zhong Wu; Xiao Junhai; Xie Yunde; Li Xingzhou; Wang Xiaokui; (24 pag.)CN107964011; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem