Adding a certain compound to certain chemical reactions, such as: 131747-41-6, 2-(Trifluoromethyl)isonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 131747-41-6, blongs to pyridine-derivatives compound. Recommanded Product: 131747-41-6
Step 1. (2-(trifluoromethyl)pyridin-4-yl)methanol To a stirred solution of 2-(trifluoromethyl)isonicotinic acid (3.9 g, 20.4 mmol) in 50 mL of THF at 0 C was added a solution of borane (45 mL of a 1.0 M solution in THF, 45 mmol) dropwise over a period of 5 min. The cooling bath was removed and the mixture was stirred at RT for 18 h. The reaction was quenched with the slow addition of water (100 mL). The mixture was extracted with two portions of EtOAc. The EtOAc extracts were combined, washed with brine, dried over MgS04, filtered, and the solvents were removed in vacuo. The crude product was chromatographed on a 40 g S1O2 column using 0-80% EtOAc:hexane over 15 min at 30 mL/min. Fractions containing product were combined and the solvents were removed in vacuo to give the title compound. LCMS m/z = 178.0 (M+H)+.
The synthetic route of 131747-41-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; WILLIAMS, Peter, D.; MCCAULEY, John, A.; BUNGARD, Christopher, J.; BENNETT, David Jonathan; WADDELL, Sherman, T.; MORRIELLO, Gregori, J.; CHANG, Lehua; DWYER, Michael, P.; HOLLOWAY, M. Katharine; CRESPO, Alejandro; CHU, Xin-Jie; WISCOUNT, Catherine; LOUGHRAN, H. Marie; MANIKOWSKI, Jesse, J.; SCHULZ, Jurgen; KEERTIKAR, Kartik, M.; HU, Bin; ZHONG, Bin; JI, Tao; WO2015/138220; (2015); A1;,
Pyridine – Wikipedia,
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