Electric Literature of 588729-99-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.588729-99-1, name is 3-Amino-5-bromo-2-chloropyridine, molecular formula is C5H4BrClN2, molecular weight is 207.4557, as common compound, the synthetic route is as follows.
(1) 5-bromo-3-amino-2-chloropyridine (0.10 g, 0.48 mmol),Pyridine (0.057g, 0.72mmol) was dissolved in dichloromethane (0.77mL) to prepare reaction solution 1, and phenylsulfonyl chloride (0.10g, 0.58mmol) was used to prepare reaction solution 2. The flow rate (0.4mL / min) set by the intelligent numerical control sampler was simultaneously introduced into the first three-way mixer (ambient temperature 0 C) through a 500 mum inner diameter picker tube and mixed, and then flowed out under its own pressure and entered In a temperature-controlled (25 C) picker tube with an inner diameter of 500 mum, the sulfonamidation reaction is completed under the condition of a set residence time t1 (1min), and then the post-pressure valve is used to obtain a first effluent;
The chemical industry reduces the impact on the environment during synthesis 588729-99-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Fudan University; Zhuhai Fudan Chuangxin Institute; Ling Yun; Zhou Yaming; Jia Yu; Deng Mingli; Liu Xiaofeng; Yang Yongtai; Chen Zhenxia; (30 pag.)CN110498798; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem