Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 87109-10-2, name is 3-Phenylpyridin-2-amine. A new synthetic method of this compound is introduced below., name: 3-Phenylpyridin-2-amine
To a solution of 3-phenylpyridin-2-amine (10.0 g, 55.8 mmol) and di-tert-butyl dicarbonate (48.7 g, 223 mmol) in DCM (200 mL) was added DMAP (13.6 g, 112 mmol) in batches. The resulting mixture was stined at 26 C for 16 h, then washed with brine (100 mL x 3), dried over Na2SO4and concentrated. The residue was purified by flash silica gel chromatography (ISCO; 120 g SepaFlash Silica Flash Column, EtOAc in petroleum ether: 0- 40%, 50 mL/min, dry loaded) to give the title compound.?H NMR (400 MHz, CDC13) oe 8.52 (d, J = 3.1 Hz, 1H), 7.75 (dd, J = 1.6, 7.4 Hz, 1H), 7.34-7.45 (m, 6H), 1.30 (s, 18H).
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Reference:
Patent; MERCK SHARP & DOHME CORP.; STUMP, Craig A.; CHEN, Yi Heng; LIU, Ping; MENG, Dongfang; WU, Jane; LI, Chun Sing; QI, Zhiqi; (163 pag.)WO2016/161572; (2016); A1;,
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