Schaub, Nicholas J.; Corey, Joseph M. published the article 《A method to rapidly analyze the simultaneous release of multiple pharmaceuticals from electrospun fibers》. Keywords: pharmaceutical extended release electrospun fiber; 6-Aminonicotinamide; Drug-delivery; Electrospun fibers; Ibuprofen; Pharmaceutical delivery.They researched the compound: 6-Aminonicotinamide( cas:329-89-5 ).Formula: C6H7N3O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:329-89-5) here.
Electrospun fibers are a commonly used cell scaffold and have also been used as pharmaceutical delivery devices. In this study, we developed a method to analyze the release of multiple pharmaceuticals from a single electrospun fiber scaffold and determine how each pharmaceutical’s loading concentration affects the release rate of each pharmaceutical. Our anal. methods were tested on electrospun fibers loaded with two pharmaceuticals: 6-aminonicotinamide (6AN) and ibuprofen. Pharmaceutical concentration in electrospun fibers ranged from 1.5% to 8.5% by weight We found that 6AN release was dependent on the concentration of 6AN and ibuprofen loaded into the fibers, while ibuprofen release was only dependent on the loading concentration of ibuprofen but not 6AN. Unexpectedly, ibuprofen release became dependent on both 6AN and ibuprofen loading concentrations when fibers were aged for 1-mo post-fabrication at room temperature in the laboratory followed by a 4-h incubation inside the cell culture incubator at 37°C and 5% CO2. One addnl. discovery was an unknown signal that was attributed to the medical grade syringes used for electrospinning, which was easily removed using our method. These results demonstrate the utility of the methods developed here and indicate multiple agents can be released concomitantly from electrospun fibers to meet the demands of more complex tissue engineering approaches. Future work will focus on anal. of pharmaceutical release profiles to exploit the dependencies on pharmaceutical loading concentrations
The article 《A method to rapidly analyze the simultaneous release of multiple pharmaceuticals from electrospun fibers》 also mentions many details about this compound(329-89-5)Formula: C6H7N3O, you can pay attention to it or contacet with the author([email protected]) to get more information.