Adding a certain compound to certain chemical reactions, such as: 823-61-0, 3,6-Dimethyl-2-pyridinamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 3,6-Dimethyl-2-pyridinamine, blongs to pyridine-derivatives compound. Safety of 3,6-Dimethyl-2-pyridinamine
a) 5-Chloro-3,6-dimethylpyridin-2-amine NCS (3.28 g, 24.6 mmol, Eq: 1.00) was added at 15 C in one portion to a solution of 3,6-dimethylpyridin-2-amine (3 g, 24.6 mmol, Eq: 1.00) in ethyl acetate (130 mL). The temperature was maintained between 20-24 C for 1 h. The red mixture was stirred overnight. The mixture was filtered. The filtrate was washed with 40% aq. sodium bisulfite solution (100 ml) and brine. The aqueous phase was extracted with EtOAc (2×100 ml). The combined organic layers were dried over Na2S04 and then concentrated to an oil. The residue was purified by column chromatography (70g Si02, 0 to 50% EtOAc/n-heptane) to afford 5-chloro-3,6-dimethylpyridin- 2-amine (1.16 g, 30.2 %) as a light yellow-brown product. MS: m/z = 157.1 (M+H+)
The synthetic route of 823-61-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KUHN, Bernd; LERNER, Christian; RUDOLPH, Markus; SCHAFFHAUSER, Herve; WO2013/178572; (2013); A1;,
Pyridine – Wikipedia,
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