Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone. A new synthetic method of this compound is introduced below., Recommanded Product: 4-Benzyloxy-2-(1H)-pyridone
A mixture of N,N-diethyl-7-iodopyrazolo[1,5-a]pyridin-3-amine (0.25 g, 0.79 mmol), 4-benzyloxy-2(1H)-pyridone (0.19 g, 0.94 mmol), copper(1) iodide (0.003 g, 0.016 mmol) and potassium carbonate (0.13 g, 0.94 mmol) in DMF (5.0 ML) was heated at 150 C. for 3 h and cooled down to room temperature.The mixture was partitioned between EtOAc and H2O and separated.The organic layer was concentrated in vacuo to dryness.The residue was subjected to column chromatography (E:H=1:4) to give 0.18 g (60%) of a clear oil as the title compound: 1H NMR (400 MHz, CDCl3) delta 7.96 (d, J=5.8 Hz, 1H), 7.81 (s, 1H), 7.48-7.43 (m, 6H), 7.12-7.08 (m, 1H), 6.80 (s, 1H), 6.74 (d, J=5.8 Hz, 1H), 6.59 (d, J=6.4 Hz, 1H), 5.19 (s, 2H), 3.14 (q, J=7.1 Hz, 4H), 1.06 (t, J=7.1 Hz, 6H); MS (EI) m/z 389.25 (M++H).
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Reference:
Patent; Fu, Jian-Min; US2004/2511; (2004); A1;,
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