Adding a certain compound to certain chemical reactions, such as: 127838-58-8, 4-(Hydroxymethyl)pyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-(Hydroxymethyl)pyridin-2(1H)-one, blongs to pyridine-derivatives compound. name: 4-(Hydroxymethyl)pyridin-2(1H)-one
To a suspension of 4-(hydroxymethyl)-2(1 /-/)-pyridinone (0.98 g, 7.9 mmol) and DMF (10 ml_) was added imidazole (0.64 g, 9.45 mmol) and ferf-butyldimethylsilyl chloride (1.25 g, 8.26 mmol), and the mixture was stirred at ambient temperature under a nitrogen atmosphere for 18 h. The mixture was poured into water (30 ml_), and stirred for 30 min. The solid was filtered, rinsed with water, and air-dried to provide 4-({[(1 ,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2(1 /-/)-pyridinone as an off-white solid (1.64 g, 88%): 1H NMR (400 MHz, DMSOd6) delta ppm 1 1.34 (br s, 1 H), 7.26 (d, J = 6.6 Hz, 1 H), 6.21 (s, 1 H), 6.01 (dd, J = 6.6, 1.5 Hz, 1 H), 4.5 (s, 2H), 0.88 (s, 9H), 0.05 (s, 6H); EI-LCMS m/z 241 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,127838-58-8, 4-(Hydroxymethyl)pyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/76387; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem