Adding a certain compound to certain chemical reactions, such as: 188057-20-7, 4-Iodopyridin-3-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 188057-20-7, blongs to pyridine-derivatives compound. Application In Synthesis of 4-Iodopyridin-3-ol
To a degassed solution of 3b (150 mg, 0.50 mmol) and a 1-halo, 2-hydroxy or thio-aryl compound (e.g., 4-iodo-3- pyridinol, 261 mg, 1.5 mmol) in DMF (5 ml) was added(with protection from light) triethylamine (0.28 ml, 2.0mmol), followed by Cul (38 mg, 0.2 mmol) and thentetrakis(triphenylphosphine)palladium (116 mg, 0.1 mmol). After sealing the reaction vessel with a rubber septum, the reaction mixture was heated in an oil bath at 40 C. for 18h. After concentrating, the methanol extract was filtered andthe filtrate chromatographed, using an elution gradient of CHCl/MeOH (95/5-90/10). Example 9 (X, YN, ZCl,R?NH2, R2, R3, R4, R7, R8H, R5, R6OH, R9CH2OH,24 mg) was recovered as yellow crystals after recrystallizing from MeOH. Analysis calculated for C,7H,8C1N504.0. 1 MeOH. 1.1 5i02: C, 44.70; H, 4.04; N, 15.24. Found: C, 44.72; H, 4.20; N, 15.24.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,188057-20-7, its application will become more common.
Reference:
Patent; Merck Sharp & Dohme Corp.; Southern Research Institute; Arasappan, Ashok; Njoroge, F. George; Kwong, Cecil D.; Ananthan, Subramaniam; Bennett, Frank; Velazquez, Francisco; Girijavallabhan, Vinay M.; Huang, Yuhua; Kezar, III, Hollis S.; Maddry, Joseph A.; Reynolds, Robert C.; Roychowdhury, Abhijit; Fowler, Anita T.; Secrist, III, John A.; Kozlowski, Joseph A.; Shankar, Bandarpalle B.; Tong, Ling; Kim, Seong Heon; MacCoss, Malcolm; Venkatraman, Srikanth; Verma, Vishal; (798 pag.)US9433621; (2016); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem