The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3222-50-2, name is 4-Methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 3222-50-2
4-Methylnicotinic acid (2.50 g, 14.4 mmol), EDCI (4.14 mg, 21.6 mmol) and HOBt (2.92 mg, 21.6 mmol) were combined in DMF (1 ml) and CH2Cl2 (75 ml) to give a pale yellow solution. To this solution was added ammonium chloride (2.31 g, 43.2 mmol) followed by DIPEA (12.5 ml, 72.0 mmol) and the resulting mixture was stirred at room temperature for 16 hours. The solvent was removed in vacuo and diluted with saturated aqueous NaHCO3 (50 ml) and CH2Cl2 (50 ml). The solution was then basicified to pH -14 with ION NaOH. The phases were separated and the aqueous layer was extracted with CH2Cl2 (5 x 50 ml). The combined organic extracts were dried (Na2SO4), filtered and concentrated under reduced pressure. The crude material was purified by flash column chromatography on silica gel (94:5:1, CH2Cl2/MeOH/NH4OH) to generate 4-methyl-nicotinamide as an off-white solid (0.95 g, 48%). 1H-NMR (CDCl3) delta 2.53 (s, 3H), 7.20 (d, IH, J= 4 Hz), 8.53 (d, IH, J= 4 Hz), 8.69 (s, IH).
With the rapid development of chemical substances, we look forward to future research findings about 3222-50-2.
Reference:
Patent; ANORMED INC.; WO2006/138350; (2006); A2;,
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