Extended knowledge of 4-Methylnicotinonitrile

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5444-01-9, name is 4-Methylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 5444-01-9

4-methylnicotinamide (7) is prepared starting from the intermediate product (6) by treatment with the ion-exchange resin Amberlite IRA- 410.The resin (400 mg), preconditioned in 10% aqueous NaOH (5 ml) for 90 minutes and washed with degassed water until the excess alkalinity disappears, is added with an aqueous solution of (6) (200 mg; 1.7 mmol), reflux heating for approximately one hour.At the end of this period the solution is filtered and the resin is washed thoroughly with 10 ml of boiling water: on adding the washing water to the filtrate, a solid residue is obtained by lyophilization, consisting in practically pure 4-methylnicotinamide (7) (220 mg; 1.6 mmol; yield 85%; m.p. 160-1610C).

With the rapid development of chemical substances, we look forward to future research findings about 5444-01-9.

Reference:
Patent; UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA; WO2008/90585; (2008); A2;,
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