In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 403-45-2, name is 6-Fluoronicotinic acid, the common compound, a new synthetic route is introduced below. Application In Synthesis of 6-Fluoronicotinic acid
A mixture of 6-fluoro-nicotinic acid (2.07g, 14.7mmol), K2CO3 (4.48g, 32.4mmol) and MeI (3.2Og, 22.5mmol) in DMF (6OmL) was stirred for 16h at rt. After dilution with H2O (5OmL), the reaction mixture was extracted with EtOAc (5OmL) and the extract washed successively with saturated NaHCO3 solution (2OmL), brine (2 x 2OmL) and dried (MgSO4). Filtration and evaporation of the solvent gave the product as an orange solid (1.79g, 78%). 1H (CDCl3) 8.53 (IH, s), 8.12 (IH, m), 6.77 (IH, dd), 3.67 (3H, s)
The synthetic route of 403-45-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JAMES BLACK FOUNDATION; WO2007/135350; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem