With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1060811-62-2, name is 4,6-Dichloronicotinaldehyde, molecular formula is C6H3Cl2NO, molecular weight is 176, as common compound, the synthetic route is as follows.Formula: C6H3Cl2NO
A pre-mixed stirred solution of compound 3 (7.4 g, 42.28 mmol) in dichloromethane (40 mL) containing triethyl amine (11.37 mL, 84.56 mmol) was added ethyl mercaptoacetate (5.59 mL, 50.74 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 1 h and then to 50 °C for 18 h. The reaction mixture was quenched with water and extracted with ethyl acetate. After usual standard work up procedure and purification by column chromatography (silica gel: 100-200 mesh, eluent: 5percent ethyl acetate in pet ether) isolated compound 4; Light Yellow solid; Yield: 5.7 g, 56 percent; m.p.: 108-112 °C. Elemental analysis of C10H8NO2SCl calcd. (found) percent: C 49.69 (49.71), H 3.34 (3.32), N 5.80 (5.77)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060811-62-2, 4,6-Dichloronicotinaldehyde, and friends who are interested can also refer to it.
Reference:
Article; Sree Lakshmana Rao; Basaveswara Rao, Mandava V.; Prasad; Asian Journal of Chemistry; vol. 31; 3; (2019); p. 627 – 632;,
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