Reference of 166526-03-0, Adding some certain compound to certain chemical reactions, such as: 166526-03-0, name is 4,6-Dichloronicotinonitrile,molecular formula is C6H2Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 166526-03-0.
A mixture of 4,6-dichloronicotinonitrile (100 mg, 0.58 mmol), 2-fluoro-5-methoxy-N-(4- (4,4,5,5 -tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenyl)benzenesulfonamide (259 mg, 0.636 mmol), Pd(dppf)C12DCM (24 mg, 0.024 mmol) and Cs2CO3 (381 mg, 1.16 mmol) in dioxane (3 mL) and H20 (0.5 mL) was heated under N2 at 100 C for 6 h. The mixture was cooled to room temperature, diluted with EtOAc (30 mL), filtered through celite, concentrated and purified by silica gel chromatography eluting with ethyl acetate in hexane (0-30 percent) to afford the title compound (244 mg, yield: 100%).
According to the analysis of related databases, 166526-03-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NEW ERA PHARMA, INC.; XIAN, Jun; (82 pag.)WO2018/106459; (2018); A1;,
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