4926-28-7 , The common heterocyclic compound, 4926-28-7, name is 2-Bromo-4-methylpyridine, molecular formula is C6H6BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 2-bromo-4-methylpyridine (1 g, 5.81mmol), NBS (1.1 g, 6.39 mmol) and a catalytic amount of AIBN (100 mg) in CCL (10 mL) was stirred at 80 C overnight. The resulting mixture was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: PE/EtOAc = 200/1) to give the desired product (500 mg).
According to the analysis of related databases, 4926-28-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; CIANCHETTA, Giovanni; LIU, Tao; PADYANA, Anil, Kumar; SUI, Zhihua; CAI, Zhenwei; CUI, Dawei; JI, Jingjing; (294 pag.)WO2019/35863; (2019); A1;,
Pyridine – Wikipedia,
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