Application of 106877-33-2, Adding some certain compound to certain chemical reactions, such as: 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine,molecular formula is C6H5F3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106877-33-2.
[0372] A stirred solution of 7-bromo-6-methylquinoline Int-1 (Example 86) (150 mg, 0.675 mmol), 6-(trifluoromethyl)pyridin-3-amine (131 mg, 0.810 mmol) and Na2CC>3 (142 mg, 1.351 mmol) in acetonitrile (5 mL) was degassed with Argon in a microwave vessel for 15 min. Then Mo(CO)6 (178 mg, 0.675 mmol), 3RhoEtaBetaEpsilon4 (19.6 mg, 0.0675 mmol) and Pd(OAc)2 (15.1 mg, 0.0675 mmol) were added, and degassing was continued for additional 10 min. Then the reaction mixture was irradiated in microwave at 90 C for 3 hrs. After completion (checked by TLC), the reaction mixture was diluted with water (20 mL) and extracted with Ethyl Acetate (2×50 mL). Combined organic layer was washed with water (2×20 mL), brine (20 mL) and dried over anhydrous sodium sulfate. The organic layer was evaporated under reduced pressure to afford crude product. The crude compound was purified by Grace (reverse phase) column chromatography using 0.05 % HCOOH in CCN as eluent to afford 50 mg (21% yield) of the desired compound 160 as an off- white solid. MS (ESI) m/z: 332.21 [M+H]+. 1H NMR (DMSO-i/6, 400 MHz): delta 11.18 (s, 1H), 9.07 (d, J = 2.0 Hz, 1H), 8.94 (dd, J = 4.4, 2.0 Hz, 1H), 8.50 (dd, J = 8.0, 1.6 Hz, 1H), 8.35 (dd, J Hz, 1H), 8.24 (s, 1H), 7 ‘.95-7 ‘.92 (m, 2H), 7.60 (dd, J= 8.4, 4.0 Hz, 1H), 2.61 (s, 3H).
According to the analysis of related databases, 106877-33-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ACTAVALON, INC.; DNEPROVSKAIA, Elena, V.; HOLZWARTH, Michael, S.; RYCHNOVSKY, Scott, D.; (184 pag.)WO2018/85348; (2018); A1;,
Pyridine – Wikipedia,
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