In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24242-20-4, name is 5-Aminopicolinic acid, the common compound, a new synthetic route is introduced below. Quality Control of 5-Aminopicolinic acid
To a solution of 5-aminopicolinic acid (194 mg, 1.40 mmol) in ethanol (5 mL), was added thionyl chloride (0.20 mL, 2.80 mmol) at 0 C. The mixture was then stirred under reflux for 19 h, after which time it was cooled to room temperature and the reaction mixture concentrated under reduced pressure. Saturated aqueous sodium carbonate solution was added to the resulting solid to adjust the pH to 9, followed by saturated aqueous sodium hydrogen carbonate. Ethyl acetate (10 mL) and water (10 mL) were added and the organic phase was washed with brine (1 0 mL), dried (Na2SO4), filtered and the filtrate concentrated in vacuo. Ethyl 5-aminopicolinate (184 mg, 79%) was obtained as an off-white solid, with no need for further purification; 1H NMR (500 MHz, MeOD) 6 1 .37 (3H, t, J = 7.1 Hz, CH3), 4.35 (2H, q, J = 7.2 Hz), 7.02 (1H, dd, J = 2.7 and 8.6 Hz, Ar), 7.85 (1H, d, J = 8.6 Hz) and 7.98 (1H, d, J= 2.7 Hz). LRMS(ESI÷) mz 167.2 [M + H].
The synthetic route of 24242-20-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; REUILLON, Tristan; MILLER, Duncan; MYERS, Stephanie; MOLYNEUX, Lauren; CANO, Celine; HARDCASTLE, Ian; RIGOREAU, Laurent; GOLDING, Bernard; NOBLE, Martin; (246 pag.)WO2016/42341; (2016); A1;,
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