Application of 88139-91-7, Adding some certain compound to certain chemical reactions, such as: 88139-91-7, name is 5-Bromo-2-hydroxymethylpyridine,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 88139-91-7.
NaH (0.525 g, 13.1 mmol, 60% in mineral oil) was added to a solution of alcohol 41 (1.872, 10.1 mmol) and 5-bromo-2-(chloromethyl)pyridine (58) (prepared by chlorination of (5-bromo-2-pyridinyl)methanol, as reported by van den Heuvel et al., 2004) (2.5 g, 12.1 mmol) in anhydrous DMF (40 rnL) at 5 0C. The resulting mixture was stirred at room temperature for 2 h and then quenched with water (300 mL). The precipitate was filtered off, washed with water and dried to give (6S)-6-[(5-bromo-2-pyridinyl)methoxy]-2-nitro-6,7- dihydro-5H-imidazo[2,l-6][l,3]oxazine (59) (3.087 g, 86%) as a light brown solid: mp 171-173 0C; 1H NMR [(CD3)2SO] delta 8.65 (dd, J= 2.3, 0.4 Hz, 1 H), 8.04 (dd, J = 8.4, 2.4 Hz, 1 H), 8.02 (s, 1 H), 7.35 (dd, J = 8.4, 0.4 Hz, 1 H), 4.72-4.66 (m, 3 H), 4.49 (br d, J= 12.0 Hz, 1 H), 4.35- 4.21 (m, 3 H). Anal. (Ci2HnBrN4O4) C, H, N. HPLC purity: 99.4%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 88139-91-7, 5-Bromo-2-hydroxymethylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT; DENNY, William, Alexander; THOMPSON, Andrew, M.; BLASER, Adrian; MA, Zhenkun; PALMER, Brian, Desmond; SUTHERLAND, Hamish, Scott; KMENTOVA, Iveta; WO2011/14774; (2011); A1;,
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