As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1072-97-5, name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 5-Bromopyridin-2-amine
Example 57b. 5-(l-Methyl-lH-pyrazol-4-yl)-pyridin-2-ylamineA mixture of 2-amino-5-bromopyridine (3.0 g, 17.3 mmol), l-methyl-4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2yl)-lH-pyrazole (5.4 g, 26.0 mmol) and potassium carbonate (3.6 g, 26.0 mmol) in dimethoxy ethane (60 mL) and water (10 mL) was degassed for 15 minutes using nitrogen. [l,l ‘-Bis(di-tert-butylphosphino)- ferrocene]palladium (II) dichloride (562 mg, 0.87 mmol) was added and the reaction mixture was heated in a sealed tube at 90 0C overnight. The mixture was cooled to room temperature and partitioned between ethyl acetate and aqueous sodium bicarbonate solution. The organic phase was separated and the aqueous layer was re-extracted with ethyl acetate. The combined extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash column chromatography using a gradient of 2 to 5% methanol in dichloromethane. The desired fractions were collected and concentrated in vacuo, and the solid obtained was washed with diethyl ether to offord the title compound (2 g, 66%).1H NMR (400 MHz, CHLOROFORM-d) delta ppm 3.94 (s, 3 H) 4.39 (br. s., 2 H) 6.53 (d, J=8.21 Hz, 1 H) 7.50 (m, 2 H) 7.66 (s, 1 H) 8.21 (d, J=2.34 Hz, 1 H). ESMS m/z: [M+l]+ 175.1
With the rapid development of chemical substances, we look forward to future research findings about 1072-97-5.
Reference:
Patent; ASTRAZENECA AB; LO-ALFREDSSON, Yvonne; PAULSEN, Kim; RAKOS, Laszlo; ROTTICCI, Didier; WALDMAN, Magnus; WO2010/132015; (2010); A1;,
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