In 2019.0 CHEM-EUR J published article about SITU CLICK-CHEMISTRY; BENZOTRIAZOLE-ASSISTED SYNTHESIS; PLASMINOGEN-ACTIVATOR SYSTEM; IN-SITU; MULTICOMPONENT REACTIONS; COMBINATORIAL CHEMISTRY; GUIDED SYNTHESIS; PROTEASE; ACETYLCHOLINESTERASE; AMINOALKYLATION in [Gladysz, Rafaela; Vrijdag, Johannes; Van Rompaey, Dries; Augustyns, Koen; De Winter, Hans; Van der Veken, Pieter] Univ Antwerp, Dept Pharmaceut Sci, Lab Med Chem UAMC, Univ Pl 1, B-2610 Antwerp, Belgium; [Vrijdag, Johannes; Lambeir, Anne-Marie] Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Univ Pl 1, B-2610 Antwerp, Belgium in 2019.0, Cited 72.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Computed Properties of C6H5NO
Target-guided synthesis (TGS) has emerged as a promising strategy in drug discovery. Although reported examples of TGS generally involve two-component reactions, there is a strong case for developing target-guided versions of three-component reactions (3CRs) because of their potential to deliver highly diversified druglike molecules. To this end, the Groebke-Blackburn-Bienayme reaction was selected as a model 3CR. We recently reported a series of druglike urokinase inhibitors, and these serve as reference compounds in the present study. Due to the limited number of literature reports on target-guided 3CRs, multiple experimental parameters were optimized here. Most challenging was the formation of imine intermediates under near-physiological conditions. This aspect was addressed by exploring chemical imine stabilization strategies. Notably, imines are also crucial intermediates of other 3CRs. Such systematic studies are strongly required for further development of the TGS domain but are largely absent in the literature. Hence, this work is intended as a reference for future multicomponent-based TGS studies.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem