Synthetic Route of 52605-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.
A stirred solution of 2-chloro-3- methoxypyridine (4.86 g, 33.8 mmol) in hydrazine hydrate (40 mL) was heated under reflux for 1.5 hours. After cooling to RT, the reaction mixture was evaporated to dryness. The resulting residue was partitioned between 10% MeOH in CHCI3 and 40% w/v aqueous potassium carbonate. The aqueous phase was isolated and extracted twice with 10% MeOH in CHCI3. The combined organic extracts were dried (Na2S04), filtered and concentrated in vacuo to give the title compound (2.7 g, 57%) as a buff solid. H NMR (300 MHz, DMSO-d6): delta 7.65 (dd, J = 5.1 and 1.3 Hz, 1H), 6.99 (dd, J = 7.7 and 1.3 Hz, 1 H) overlapped with 6.98 (br s, 1 H), 6.56 (dd, J = 7.6 and 5.1 Hz, 1 H), 4.05 (br s, 2H), 3.76 (s, 3H). LCMS (Method A): RT = 0.34 nrtin, [M+H]+ = 140.
The chemical industry reduces the impact on the environment during synthesis 52605-96-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ALMAC DISCOVERY LIMITED; BELL, Mark Peter; O’DOWD, Colin Roderick; ZHANG, Lixin; TEVITT, Graham Peter; HARRISON, Timothy; BATTACHARYYA, Sumita; ROUNTREE, James Samuel Shane; BURKAMP, Frank; PRICE, Stephen; MACLEOD, Calum; ELLIOTT, Richard Leonard; SMITH, Phillip; BLENCH, Toby Jonathan; DYKE, Hazel Joan; WO2011/33265; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem