Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 54189-82-1, name is 6-Chloro-N-methylnicotinamide. A new synthetic method of this compound is introduced below., SDS of cas: 54189-82-1
A mixture of 5-[(l-cyclobutylpiperidin-4-yl)oxy]-l,3-dihydrospiro[indene-2,4′- piperidine] (50 mg), 6-chloro-N-methylnicotmamide (37 mg) and K2CO3 (30 mg) in DMSO (5 mL) is heated at 12O0C overnight. The mixture is cooled to rt and water (20 mL) is added. The resulting mixture is extracted with DCM (20 mL x 2). The combined organic phase is washed with water, dried over Na2SO4, and the solvent is removed to give a residue which is purified through PTLC (5% TEA in EtOAc) to give the title compound. MS (M+ 1) 475.6.
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Reference:
Patent; NEUROGEN CORPORATION; WO2009/39431; (2009); A2;,
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