Reference of 573675-27-1 , The common heterocyclic compound, 573675-27-1, name is 3-Amino-5-bromopicolinonitrile, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 2A mixture of compound K2 (1 g, 5.05 mmol) and sodium acetate (829 mg, 10.1 mmol) in formic acid (50 mL) was stirred at reflux overnight, and then concentrated. Sodium hydroxide (3M) was added to the residue; the mixture was stirred for 10 min and filtered. The solid was washed with water and resuspended in hydrochloride (3M), stirred for another 10 min. The solid was collected and dried to give compound K3 (0.8 g). MS for K3: m/e = 226 and 228 (M+l).
The synthetic route of 573675-27-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, Wen-Lian; HE, Shuwen; WALSH, Shawn, P.; CUMMING, Jared, N.; (70 pag.)WO2016/118404; (2016); A1;,
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