The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59020-10-9, name is 3-(Tributylstannyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 59020-10-9
A stirred solution of 3-amino-5-bromo-benzotrifuoride (Apollo, England ; 1.12 g, 5 [MMOL)] and 3- (tri-n-butylstannyl) pyridine (Maybridge Chemical Co. Ltd., England ; 2.0 g, 5.4 [MMOL)] in xylene (30 mL) was purged with argon for 10 minutes at [20C.] Tetrakis (triphenylphosphine)- palladium (0) (1. 16 g, 1.0 [MMOL)] is then added and the resulting mixture is heated at [140C] for 36 hours under an argon atmosphere. The mixture is then cooled, treated with an aqueous solution of sodium hydroxide (100 mL of 0.1 M) and purged with air for 2 hours. The resulting mixture is then diluted with ethylacetate (200 mL) and filtered. The orgainic phase is then sequentially washed with water (2 x 80 mL) and saturated aqueous sodium chloride (1 x 80 mL), dried (MgSO4), filtered and the solvent is evaporated off under reduced pressure to yield the crude product which is purified by column chromatography (silica gel, eluent ethyl acetate) to afford the title compound as a brown [OIL. 1H-NMR] (400 MHz, [DMSO-D6,] [8)] : 5.73 (br s, 2H), 6.83 (dd, 1 H), 6.99 (d, 1 H), 7.04 (d, 1 H), 7.39 (dd, 1 H), 7.64 (d, [1 H),] 8.42 (m, 1 H) and 8. 53 (dd, [1 H).]
With the rapid development of chemical substances, we look forward to future research findings about 59020-10-9.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/5281; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem