Application of 59290-81-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 59290-81-2, name is 2-Methyl-5-nitro-3-pyridinecarboxylic acid. A new synthetic method of this compound is introduced below.
A solution of 2-methyl-5-nitronicotinic acid 1 (50 mg, 0.27 mmol), intermediate III (90 mg, 0.41 mmol), PyBOP (281 mg, 0.54 mmol) and DIEA (0.14 ml, 0.81 mmol) in DCM/DMF (6 ml, 5:1) was stirred at 20C for 16 hr. The mixture was washed with sat. aq. NaHCO3, H2O, dried over MgSO4, evaporated and the brown residue was chromatographed on reverse phase HPLC (10-95% AcN in H2O) to give 8 (100 mg) as a brown solid. (Calculated mass: 386.4, observed mass: 386.5).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,59290-81-2, 2-Methyl-5-nitro-3-pyridinecarboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; KEMIA, INC.; WO2007/56016; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem