Adding a certain compound to certain chemical reactions, such as: 6188-25-6, 6-Chloroimidazo[1,2-a]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 6-Chloroimidazo[1,2-a]pyridine, blongs to pyridine-derivatives compound. Safety of 6-Chloroimidazo[1,2-a]pyridine
(ii) The whole amount of 7beta-[2-(2-amino-5-chlorothiazol-4-yl)-2(Z)-(carboxymethoxyimino)acetamido]-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acid, 2.5 g of 6-chloroimidazo[1,2-a]pyridine and 2 g of sodium iodide are mixed in 20 ml of 50% acetonitrile in water and the mixture is heated at 70 C. for 90 minutes with stirring, and then cooled to room temperature. Two grams of sodium bicarbonate is added to the reaction mixture and the mixture is chromatographed on a column of silica gel (50 g). The column is washed with 0.3 l of acetone and then with 0.5 l of acetone_water=8:1 and the product is then eluted with acetone_water=5:2. Fractions containing the objective compound are concentrated and the residue is placed on a column of Sephadex LH-20 (Pharmacia Inc., Sweden) and eluted with water. Fractions containing the objective compound are lyophilized to give the above-identified compound. Elemental analysis for C22 H16 Cl2 N7 NaO7 S2.2H2 O: Calcd.(%): C, 38.60; H, 2.95; N, 14.33. Found (%): C, 38.40; H, 2.99; N, 14.06. IR spectrum numaxKBr cm-1: 1770, 1680, 1620, 1520, 1440, 1320. NMR spectrum (d6 -DMSO)delta: 2.04 and 3.40(2H, ABq, J=18 Hz), 4.25(2H, br.s), 4.97(1H, d, J=5 Hz), 5.40(2H, br.s), 5.66(1H, d. d, J=5 Hz and 8 Hz), 7.31(2H, br.s), 8.05(1H, d, J=6 Hz), 8.40(1H, d, J=3 Hz), 8.58(1H, d, J=7 Hz), 9.28(1H, br. s), 9.77(1H, d, J=6 Hz).
The synthetic route of 6188-25-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US4788185; (1988); A;,
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