Reference of 1122-71-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1122-71-0, name is 6-Methyl-2-pyridinemethanol. A new synthetic method of this compound is introduced below.
Example 45 2-[(6-Methylpyridin-2-yl)methoxy]-4-(2-methylpyrimi din-5-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine hydrochloride To 2-chloro-4-(2-methylpyrimidin-5-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine (100 mg), (6-methylpyridin-2-yl)methanol (52 mg), t-Bu-X-Phos (55 mg), and cesium carbonate (398 mg) and Pd2 (dba)3¡¤CHCl3 (34 mg) was added toluene (2.2 mL), and the mixture was degassed, then stirred under Ar atmosphere at 100C for 6 hours. After the reaction mixture was allowed to return to room temperature, diluted with ethyl acetate, filtered through Celite, and the filtrate was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography to give 2-[(6-methylpyridin-2-yl)methoxy]-4-(2-methylpyrimi din-5-yl)-6,7-dihydro-5H-cyclopenta[b]pyridine (49 mg). Theresulting compound was dissolved in ethyl acetate (2 mL) and 1N HCl/Et2O solution (0.147 mL) was added, then themixture was stirred under ice water cooling for 3 hours. The resulting precipitate was collected by filtration to give thetitle compound (43 mg) as a white powder.[MS (ESI) m/z 333.4 (M+H)+]
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-71-0, its application will become more common.
Reference:
Patent; Nippon Shinyaku Co., Ltd.; TSUJI, Takashi; SHIRAI, Masaaki; EP2891656; (2015); A1;,
Pyridine – Wikipedia,
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