Adding a certain compound to certain chemical reactions, such as: 19621-92-2, 6-Oxo-1,6-dihydropyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 6-Oxo-1,6-dihydropyridine-2-carboxylic acid, blongs to pyridine-derivatives compound. Safety of 6-Oxo-1,6-dihydropyridine-2-carboxylic acid
At 25 C and N 2 atmosphere,To 6-hydroxypyridine-2-carboxylic acid (12 mmol)And pyridine (20 mmol)Add 20 mL of anhydrous dichloromethane solution1,3-Dicyclohexylcarbodiimide DCC (15 mmol).5 minutes later,Add 2-((1-Amino-2-methylpropan-2-yl)amino)-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)ethanone (10 mmol ),The mixture was stirred overnight.TLC (95:5 in dichloromethane:Methanol containing 2% ammonia)Indicates that all raw materials are consumed.The reaction was quenched with sodium bicarbonate and filtered through a pad of Celite.The stopper was rinsed with methylene chloride.The aqueous layer was extracted with dichloromethane.After the combined organic layers are dried over Na 2 SO 4 ,Filter and concentrate in vacuo,This gave 3.5 g of a light brown solid.The crude product was purified by flash chromatography.Use 2% to 8% MeOH:Purification by stepwise gradient of dichloromethane and 2% ammonia,Obtained 3.2 g of white powder as N-(2-((2-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-2-ethoxy)amino)-2-methylpropane ()-(6-hydroxypyridin-2-yl)-carboxamide,The yield was 94%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,19621-92-2, 6-Oxo-1,6-dihydropyridine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Sang Qi; (10 pag.)CN108218865; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem