Extended knowledge of 6-(tert-Butyl)nicotinic acid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,832715-99-8, its application will become more common.

Reference of 832715-99-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 832715-99-8 as follows.

A mixture of [6-(3-amino-2-methyl-phenyl)-imidazo[l,2-a]pyrazin-8- yl]-(4-morpholin-4-ylmethyl-phenyl)-amine (150mg; 0.36mmol), benzotriazol-1- yloxytris(dimethylamino)phosphonium hexafluorophosphate (450mg; l.Ommol), and diisopropylethylamine (0.3mL; 1.7mmol) is dissolved in dimethylacetamide (ImL) and stirred at room temperature for 20min. 6-te/t-butyl-nicotinic acid (200mg; l.lmmol) is added and the mixture is stirred at room temperature for 16hr.[00297] Water (1OmL) is added and the mixture is filtered to give 6-?err-Butyl-N-{2-methyl-3-[8-(4-morpholin-4-ylmethyl-phenylamino)-imidazo[l,2-a]pyrazin-6- yl] -phenyl} -nicotinamide as a crude tan solid (120mg). The crude solid is purified by flash chromatography over silica gel to provide the final compound as a pale cream solid (lOOmg)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,832715-99-8, its application will become more common.

Reference:
Patent; CGI PHARMACEUTICALS, INC.; WHITNEY, James A.; DI PAOLO, Julie; VALLECA, Mark A.; BRITELLI, David R.; CURRIE, Kevin S.; DARROW, James W.; KROPF, Jeffrey E.; LEE, Tony; GALLION, Steven L.; MITCHELL, Scott A.; PIPPEN, Douglas A.I.; BLOMGREN, Peter A.; STAFFORD, Douglas Gregory; WO2008/33858; (2008); A2;,
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