605-38-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 605-38-9, name is Dimethyl pyridine-2,3-dicarboxylate. A new synthetic method of this compound is introduced below.
To the solution of dimethyl pyridine-2,3-dicarboxylate (32 g, 164 mmol) in EtOH/H2O (10:1, 440 mL) was added NaBH4 (32 g, 842 mmol) portionwise over 30 min, and the mixture stirred at r.t. overnight. Acetone and EtOAc were added, and the mixture was filtered through a silica gel pad, and evaporated under vacuum to give a yellow solid. This was dissolved in EtOAc/MeOH (5:1), passed through a silica gel pad, and evaporated to give pyridine-2,3-diyldimethanol as a yellow solid. Yield 3.2 g, 14percent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,605-38-9, Dimethyl pyridine-2,3-dicarboxylate, and friends who are interested can also refer to it.
Reference:
Patent; MICURX PHARMACEUTICALS, INC.; WO2008/108988; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem