626-64-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-64-2, name is Pyridin-4-ol, the common compound, a new synthetic route is introduced below.
To a solution of tert-butyl 3-hydroxyazetidine-1-carboxylate 1 (4.55 g, 26.3 mmol) inTHF (100 mL) was added pyridin-4-ol (2.0 g, 21.0 mmol), PPh3 (6.89 g, 26.3 mmol)and DEAD (4.57 g, 26.3 mmol). The resulting reaction mixture was stirred at 70 Covernight. TLC indicated that the reaction was complete. The reaction mixture wasconcentrated in vacuum. The resulting oil was dissolved in 1 .0 M aqueous HCI solution C 20 mL) and extracted with DCM (50 mL x 3), The combined organic phases were washed with HCI (aq) solution (0.5 M, 150 mL). The aqueous fractions were combined and basified to pH12 using NaOH (1.0 M) and extracted with DCM(100 mL x 3) . The combined organic phases were dried over anhydrous Na2SO4,filtered and concentrated in vacuum. The residue was purified by column chromatography on silica gel to afford to afford 4 (2.81 91 53% yield) as a solid.1HNMR (400 MHz, DMSO-d6): 5 8.41 (d, J 6.0 Hz, 2 H), 6.88 (d, J = 6.0 Hz, 2 H),5.07-5.09 (m, 1 H), 4.32-4.33 (m, 2 H), 3.80-3.82 (m, 2 H)3 1.39 (s, 9 H). MS Calcd.:250; MS Found: 251 ([M+Hfl.
Statistics shows that 626-64-2 is playing an increasingly important role. we look forward to future research findings about Pyridin-4-ol.
Reference:
Patent; H. LUNDBECK A/S; SVENSTRUP, Niels; WEN, Kate; WANG, Yazhou; (78 pag.)WO2017/5786; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem