As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6318-51-0, name is (4-Chlorophenyl)(pyridin-2-yl)methanone, molecular formula is C12H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6318-51-0
To a stirred solution of N-((4-fluorophenyl)(pyridin-2-yl)methyl)piperidine-4-carboxamide (key Intermediate-TV) (0.150 g, 0.479 mmol) in DCE (3 mL) were added benzofuran-2- carbaldehyde (0.07 g, 0.479 mmol, 1 equiv), and acetic acid (0.0287 g, 0.479 mmol,at 0 C and the reaction was stirred at room temperature for ih. Then sodium triacetoxy borohydride (0.281 g, 1.43 mmol, 3 equiv) was added. After completion, the reactionwas quenched with water and pH was adjusted -7 with saturated NaHCO3 solutionextracted with CH2C12. The combined organic extract was dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude compound was purifiedHPLC to afford 0.040 g of 1-(benzofuran-2-ylmethyl)-N-((4-fluorophenyl)(pyridin-2- yl)methyl)piperidine-4-carboxamide (Yield =19Title compound was prepared by reductive amination of (4-chlorophenyl)(pyridin-2-yl)methanone (1 g, 4.59 mmol) using the general methodology of Example-59 and afforded0.5 g of 1 -(4-chlorophenyl)-N-methyl- 1 -(pyridin-2-yl)methanamine (Yield = 47%).
With the rapid development of chemical substances, we look forward to future research findings about 6318-51-0.
Reference:
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (323 pag.)WO2016/100823; (2016); A1;,
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