The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.
Related Products of 63237-88-7 , The common heterocyclic compound, 63237-88-7, name is Pyrazolo[1,5-a]pyridine-2-carboxylic acid, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 132N-((ls,4s)-4-(5-fluoro-2-(4′-(3-(piperazin-l-yl)propyl)biphenyl-3- yloxy)nicotinamido)cyclohexyl)pyrazolo [ 1 ,5-a] pyridine-2-carboxamide To a solution of tert-butyl 4-(3-(3′-(3-((ls,4s)-4-aminocyclohexylcarbamoyl)-5-fluoropyridin- 2-yloxy)biphenyl-4-yl)propyl)piperazine-l-carboxylate (150 mg, 0.24 mmol) in acetonitrile (2 mL) was added pyrazolo[l,5-a]pyridine-2-carboxylic acid (38.5 mg, 0.24 mmol) and triethylamine (0.331 mL, 2.37 mmol). 1-Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (0.159 mL, 0.25 mmol) was then added and the mixture stirred at RT for 1 h. The mixture was poured into sat NaHCO3 (aq) and the organics extracted into EtOAc (x2). The extractions were combined, dried (MgSO4) and evaporated to give a residue. This was dissolved in dichlormethane (2mL) to which TFA (2mL) was added and the mixture stirred at RT for 20 min. The solvents were removed in vacuo and the residue dissolved in methanol and purified using reverse phase preparative chromatography using eluent = TFA(aq)/MeOH. The appropriate fractions were combined and evaporated to give a residue which on trituration with ether gave a solid. The solid was dried overnight under vacuum at 40 0C to give the title compound. Yield: 58 mg1H NMR (400 MHz, CD3OD) delta 8.49 (d, J= 7.2 Hz, IH), 8.41 (d, J= 6.9 Hz, IH), 8.12 (d, J = 3.1 Hz, IH), 8.07 (dd, J= 7.9, 3.1 Hz, IH), 7.66 (d, J= 9.0 Hz, IH), 7.50 – 7.45 (m, 4H), 7.42 – 7.41 (m, IH), 7.25 – 7.20 (m, IH), 7.18 – 7.13 (m, 3H), 6.96 – 6.92 (m, 2H), 4.17 – 4.12 (m, IH), 4.04 – 3.98 (m, IH), 3.41 (t, J= 5.4 Hz, 4H), 3.24 – 3.19 (m, 4H), 2.94 – 2.89 (m, 2H), 2.64 (t, J= 7.6 Hz, 2H), 1.99 – 1.68 (m, 10H). MS: [M+H]+=676 (calc=676) (MultiMode+)
The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem