Electric Literature of 6515-09-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6515-09-9, name is 2,3,6-Trichloropyridine, molecular formula is C5H2Cl3N, molecular weight is 182.4351, as common compound, the synthetic route is as follows.
500 g of 2.3.6-trichloropyridine,1800g methanol,20 g of mixed catalyst (8% Pt / C: 8% Pd / C = 1: 10)And 45g pyridine was added to the reactor,Introducing hydrogenAt the same time slowly dropping 5% by weight of sodium hydroxide methanol solution,Maintain the reactor pressure is 0.3Mpa,The temperature is 30 ,After the hydrogenation is completed,Replacement of hydrogen,Filtered out Pt / C and Pd / C catalyst applied,Receive the filtrate atmospheric distillation recovery of methanol,The remaining material by adding water,Cooling crystallization,Centrifuge,Purification gives 2,3-dichloropyridine.The purity of 2,3-dichloropyridine in step (a) is 97.6%The yield of 88.5% after the crystallization without purification gas chromatogram shown in Figure 1.
Statistics shows that 6515-09-9 is playing an increasingly important role. we look forward to future research findings about 2,3,6-Trichloropyridine.
Reference:
Patent; Jiangsu Fubiya Chemicals Co., Ltd.; Chen Mingguang; Wu Bangyuan; Shi Zhongfeng; Zhang Wenzhong; Xu Jun; (16 pag.)CN106588758; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem